(TOP)   2012

10.- Stereoselective Synthesis by Olefin Metathesis and Characterization of n-Carotene (7,8,7',8'-tetrahydro-ß,ß-carotene) Fontán N, Álvarez R, de Lera AR Journal of Natural Products 2012, on line

9.- Modulation of RXR function through ligand design Pérez E, Bourguet W, Gronemeyer H, de Lera AR Biochimica et Biophysica Acta 2012, 1821, 57–69

8.- Strong Metallophilic Interactions in the Palladium Arylation by Gold Aryls Pérez-Temprano MH, Casares JA, de Lera AR, Álvarez R, Espinet P. Angew Int. Ed. Chem., 2012, 51, on line

7.- Characterization of [8-ethyl]-chlorophyll c3 from Emiliania huxleyi Álvarez S, Zapata M, Garrido JL, Vaz B Chemical Communication, 2012, on line

6.- DFT-Based Insights into Pd -Zn Cooperative Effects in Oxidative Addition and Reductive Elimination Processes Relevant to Negishi Cross-Couplings González-Pérez AB, Álvarez R, Faza ON, Lera AR, Aurrecoechea JM Organometallics, 2012, 31, 2053- 2058

5.- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity Soto S, Vaz E, Dell’Aversana C, Álvarez R, Altucci L, de Lera AR. Org. Biomol. Chem., 2012, 10, 2101-2112

4.- Palladium-Catalyzed Intermolecular C(sp3)-H Amidation Iglesias A, Alvarez R, de Lera AR, Muñiz K Angew Int. Ed. Chem., 2012, 51, 2225-2228.

3.- Stereocontrolled synthesis of (S )-9- cis-4-oxo-13,14-dihydroretinoic acid Domínguez M, Alvarez S, Alvarez R, de Lera AR. Tetrahedron, 2012, 68, 1756-1761

2.- Synthesis of Tetrahydrodibenzofuran and Tetrahydrophenanthridinone Skeletons by Intramolecular Nucleopalladation/Oxidative Heck Cascades Martínez C,Aurrecoechea JM, Madich Y,Denis JG, de Lera AR, Álvarez R. European Journal of Organic Chemistry 2012, 99-106.

1.- A general LbL strategy for the growth of pNIPAM microgels on Au nanoparticles with arbitrary shapes Fernández-López C,Pérez-Balado C, Pérez-Juste,Pastoriza-Santos, de Lera AR, Liz-Marzán LM. Soft Matter 2012, Advance Article

(TOP)   2011

17.- Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008 Nebbioso A.; Pereira R, Khanwalkar H, Matarese F, Garcia-Rodriguez J, Miceli M, Logie C, Kedinger V, Ferrara F, Stunnenberg HG, de Lera AR, Gronemeyer H, Altucci L. Molecular Cancer Therapeutics 2011, 10, 2394-2404

16.- Epigenetic Multiple Modulators Álvarez R, Altucci L, Gronemeyer H, de Lera AR Current Topics in Medicinal Chemistry 2011, 11, 2749-2787

15.- Synthesis of C40-Symmetrical Fully-Conjugated Carotenoids by Olefin Metathesis Fontán N, Domínguez M, Álvarez R, de Lera AR. European Journal of Organic Chemistry 2011, 6704-6712.

14.- Residual Dipolar Coupling Enhanced NMR Spectroscopy and Chiroptics: A Powerful Combination for the Complete Elucidation of Symmetrical Small Molecules Pérez-Balado C, Sun H, Griesinger c, de Lera AR, Navarro-Vázquez A. Chemistry European Journal, 2011, 17, 11983-11986.

13.- Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B García-Domínguez P, Lepore I, Erb C, Gronemeyer H, Altucci L, Álvarez R and de Lera AR. Organic & Biomolecular Chemistry, 2011, 9, 6979-6987.

12.- DFT-Based Mechanistic Insights Into Noble Metal-Catalyzed Rearrangement of Propargylic Derivatives: Chirality Transfer Processes Nieto Faza O. and de Lera AR. Topics in Current Chemistry, 2011, 302, 81-130.

11.- Bond Ellipticity As a Measure of Electron Delocalization in Structure and Reactivity Silva López C. and de Lera AR. Current Organic Chemistry, 2011, 15, 3576-3593.

10.- Epigenetic Profiling of the Antitumor Natural Product Psammaplin A and Its Analogues García-Rodríguez J, Franci G, Pereira R, Benedetti R, Nebbioso A, Rodríguez-Barrios F, Gronemeyer H, Altucci L, de Lera AR. Bioorganic & Medicinal Chemistry 2011; 19, 3637-3649

9.- Design and Stereoselective Synthesis of Retinoids with Ferrocene or N-Butylcarbazole Pharmacophores that Induce Post-Differentiation Apoptosis in Acute Promyelocytic Leukemia Cells Ivanova D, Gronemeyer H, de Lera AR ChemMedChem 2011, 6, 1-13

8.- Computational Study of the Intramolecular Pericyclic Reactions of Aldazines and Some Pseudopericyclic Variants González-Pérez AB, Souto JA, Silva-López C, de Lera AR Eur. JOC 2011, 16, 2933-2939

7.- Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Pérez E, de Lera AR, Chambon P, Krezel W Biol Psychiatry 2011, 69, 788-794

6.- Retinoid-Independent Motor Neurogenesis From Human Embryonic Stem Cells Reveals A Medial Columnar Ground State Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Álvarez S, de Lera AR, Wyllie DJA, Compston DAS, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S. Nature Comm. 2011 online

5.- On the Memory of Chirality in Gold(I)-Catalyzed Intramolecular Carboalkoxylation of Alkynes Nieto-Faza O, Silva-Lopez C, de Lera AR JOC 2011, 76, 3791-3796

4.- Enantioselective Conjugate Addition of Nitro Compounds to alpha,beta-Unsaturated Ketones: An Experimental and Computational Study. Manzano R, Andrés JM, Álvarez R, Muruzábal MD, de Lera AR, Pedrosa R. Chemistry Eur. J. 2011; 17 (21) 5931-5938

3.- Separation of regioisomers and enantiomers of underivatized saturated and unsaturated fatty acid monoacylglycerols using enantioselective HPLC . García P, Franco P, Alvarez R. de Lera AR. J. Sep. Sci. 2011, 34, 999-1003

2.- Production of hemicellulosic sugars from Pinus pinaster wood by sequential steps of aqueous extraction and acid hydrolysis. González-Muñoz JM, Alvarez R, Santos V, Parajó JC. Wood Sci Technol 2011, 46, 271-285

1.- Retinoic acid receptor modulators: a perspective on recent advances and promises. Alvarez S, Bourguet W, Gronemeyer H, de Lera AR. Expert Opin Ther Pat. 2011, 21: 55-63.

(TOP)   2010

15.- Concise total synthesis and structural revision of (+)-pestalazine B.
Pérez-Balado C, de Lera AR. Org Biomol Chem. 2010 Nov 21;8(22):5179-86.

14.- Inverse agonists and antagonists of retinoid receptors.
Bourguet W, de Lera AR, Gronemeyer H. Methods Enzymol. 2010, 485:161-95.

13.- A General Synthesis of Alkenyl-Substituted Benzofurans, Indoles, and Isoquinolones by Cascade Palladium-Catalyzed Heterocyclization/Oxidative Heck Coupling
Rosana Alvarez, Claudio Martínez, Youssef Madich, J. Gabriel Denis,José M. Aurrecoechea, and Angel R. de Lera
Chem. Eur. J. 2010, 16, 12746.

12.- Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
Noelia Urbán, Raquel Martín-Ibáñez, Cristina Herránz, Miriam Esgleas, Empar Crespo, Mónica Pardo1, Iván Crespo-Enríquez, Héctor R Méndez-Gómez, Ronald Waclaw, Christina Chatzi, Susana Alvarez, Rosana Alvarez, Gregg Duester, Kenneth Campbell, Angel R de Lera, Carlos Vicario-Abejón, Salvador Martínez, Jordi Alberch, Josep M Canals
Neural Development 2010, 5:21

11.- New Anacardic Acid-Inspired Benzamides, Histone Lysine Acetyltransferase Activators
José A. Souto, Rosaria Benedetti, Kattarina Otto, Marco Miceli, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
ChemMedChem 2010, 5, 1530 - 1540

10.- Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies
Roberto Sanz, Delia Miguel, Mukut Gohain, Patricia García-García, Manuel A. Fernández-Rodríguez, Adán González-Pérez, Olalla Nieto-Faza, Angel R. de Lera, and Félix Rodríguez
Chem. Eur. J. 2010, 16, 9818 – 9828.

Corrigendum: Synthesis of Diverse Indole-Containing Scaffolds by Gold(I)-Catalyzed Tandem Reactions of 3-Propargylindoles Initiated by 1,2-Indole Migrations: Scope and Computational Studies Chem. Eur. J. 2011,17, 13117.

9.- Competing Thermal Electrocyclic Ring-Closure Reactions of (2Z)-Hexa-2,4,5-trienals and Their Schiff Bases. Structural, Kinetic, and Computational Studies.
José A. Souto, Martín Pérez, Carlos Silva López, Rosana Alvarez, Alicia Torrado and Angel R. de Lera
The Journal of Organic Chemistry, 2010 vol 75 (13), 4453-4462

8.- A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
Albane le Maire, Catherine Teyssier, Cathie Erb, Marina Grimaldi, Susana Alvarez, Angel R de Lera, Patrick Balaguer, Hinrich Gronemeyer, Catherine A Royer, Pierre Germain and William Bourguet
Nature Structural & Molecular Biology, 2010, Vol 17, 801–807

7.- A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Angel R. de Lera, Feliu Maseras, Rosana Alvarez, and Pablo Espinet
Organometallics 2010, 29 (21), 4983–4991

6.- Synthesis and Biological Characterization of the Histone Deacetylase Inhibitor Largazole and C7- Modified Analogues
José A. Souto, Esther Vaz, Ilaria Lepore, Ann-Christin Poeppler, Gianluigi Franci, Rosana Alvarez, Lucia Altucci, and Angel R. de Lera
J. Med. Chem. 2010, 53, 4654–4667

5.- Determination of the geometry of acetoxyendiynes and acetoxyenynes by NMR heteronuclear ¹³C–¹H scalar couplings and ¹³C NMR chemical shifts. Structural assignment of the oxylipin natural products peyssonenynes A and B.
Patricia García, Manuel Martín-Pastor, Angel R. de Lera and Rosana Alvarez
Magn. Reson. Chem. 2010, 48, 543–549

4.- Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan
Demian Koop, Nicholas D. Holland, Marie Sémon, Susana Alvarez, Angel R. de Lera, Vincent Laudet, Linda Z. Holland and Michael Schubert.
Developmental Biol. 2010 Feb 1;338(1):98-106

3.- Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia.
Clugston, R. D.; Zhang, W.; Alvarez, S.; de Lera, A. R.; Greer J. J.
Am. J. Resp. Cell Mol. Biol. 2010 Mar; 42(3):276-85

2.- Increased adiposity in the retinol saturase-knockout mouse.
Alexander R. Moise, Glen P. Lobo, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Kris Flask, Angel R. de Lera, Johannes von Lintig, and Krzysztof Palczewski.
FASEB Journal (2010), 24(4), 1261-1270

1.- FTY720 Stimulates 27-Hydroxycholesterol Production and Confers Atheroprotective Effects in Human Primary Macrophages
Tomas Blom, Nils Bäck, Aino-Liisa Mutka, Robert Bittman, Zaiguo Li, Angel de Lera, Petri T. Kovanen, Ulf Diczfalusy, Elina Ikonen.
Circulation Research. 2010;106:720-729

(TOP)   2009

23.- Retinoic acid and Wnt/β-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus
Takayuki Onai, Hsiu-Chin Lin, Michael Schubert, Demian Koop, Peter W. Osborne, Susana Alvarez, Rosana Alvarez, Nicholas D. Holland and Linda Z. Holland
Developmental Biology, 2009, Volume 332, Issue 2, Pages 223-233

22.- Selective, potent PPARγ agonists with cyclopentenone core structure
M. Paz Otero, Efrén Pérez Santín, Fátima Rodríguez-Barrios, Belén Vaz and Angel R. de Lera
Bioorg. Med. Chem. Lett.,2009, 19, 1883–1886.

21.- Activation of retinoic acid receptors by dihydroretinoids
Alexander R. Moise, Susana Alvarez, Marta Domínguez, Rosana Alvarez, Marcin Golczak, Glenn P. Lobo, Johannes von Lintig, Angel R. de Lera, and Krzysztof Palczewski.
Molecular Pharmacol. 2009 76(6) 1228-1237

20.- C3 Halogen and C8’’ Substituents on Stilbene Arotinoids Modulate Retinoic Acid Receptor Subtype Function.
Susana Alvarez, Harshal Khanwalkar, Rosana Alvarez, Cathie Erb, Claudio Martínez, Fátima Rodríguez-Barrios, Pierre Germain, Hinrich Gronemeyer, and Angel R. de Lera.
ChemMedChem 2009, 4, 1630 – 1640.

19.- Total synthesis of the natural isoprenylcysteine carboxyl methyltransferase inhibitor spermatinamine.
José García, Raquel Pereira, Angel R. de Lera.
Tetrahedron Letters 2009, 50, 5028–5030.

18.- Stereocontrolled and Versatile Total Synthesis of Bispyrrolidinoindoline Diketopiperazine Alkaloids: Structural Revision of the Fungal Isolate (+)-Asperdimin
Carlos Pérez-Balado, Paula Rodríguez-Graña, and Angel R. de Lera
Chem. Eur. J. 2009, 15, 9928 – 9937.

17.- Growth Factor-Antagonized Rexinoid Apoptosis Involves Permissive PPARg/RXR Heterodimers to Activate the Intrinsic Death Pathway by NO.
Pattabhiraman Shankaranarayanan, Aurélie Rossin, Harshal Khanwalkar, Susana Alvarez, Rosana Alvarez, Annica Jacobson, Angela Nebbioso, Angel R. de Lera, Lucia Altucci, and Hinrich Gronemeyer
Cancer Cell 2009, 16, 220–231.

16.- Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers.
Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
J. Med. Chem. 2009, 52(10), 3150–3158.

15.- Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists.
Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2009, 17(13), 4345-4359.

14.- Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
ChemMedChem, 2009, 4(5), 780-791.

13.- Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera.
ChemBioChem, 2009, 10(7), 1252-1259.

12.- Regulation of Hoxb4 induction after neurulation by somite signal and neural competence
Gayana S Amirthalingam, Sara Howard, Susana Alvarez, Angel R de Lera, and Nobue Itasaki
BMC Dev Biol. 2009; 9: 17.

11.- Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
Chem. Eur. J. 2009, 15(8), 1944 - 1956

10.- The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment.
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
J. Am. Chem. Soc. 2009, 131(10), 3650-3657

9.- Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana.
Org Lett 2009, 11 (5), pp 1083–1086

8.- Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels.
Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
Chemico-Biological Interactions 2009, 178(1-3) 171–177

7.- Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin.
Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga.
Photochemistry and Photobiology 2009, 85(2) March/April, 485-493

6.- Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
European Journal of Medicinal Chemistry, 2009, in press, online 1-13

5.- Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
J. Nutrit. Biochem., 2009, Volume 20 Issue 11, Pages 848-59, 859.e1-5

4.- Torquoselectivity in the electrocyclic ring-opening of cyclopropyl anions
Faza, O.N., Silva López, C., González-Pérez, A.B., Pérez-Rodríguez, M., De Lera, A.R.
Journal of Physical Organic Chemistry, 2009, 22, 378-385

3.- Mechanism of the gold-catalyzed rearrangement of (3-acyloxyprop-1-ynyl) oxiranes: A dual role of the catalyst
Pérez, A.G., Silva López, C., Marco-Contelles, J., Faza, O.N., Soriano, E., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 2982-2991

2.- Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. the anti-Woodward-Hoffmann quest (II)
Silva López, C., Faza, O.N., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 2396-2402

1.- Complex thermal behavior of 11-cis-retinal, the ligand of the visual pigments
Silva López, C., Alvarez, R., Domínguez, M., Faza, O.N., De Lera, A.R.
Journal of Organic Chemistry, 2009, 74, 1007-1013

(TOP)   2008

14.- NOVEL DERIVATIVES OF PSAMMAPLIN A, A METHOD FOR THEIR SYNTHESIS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF CANCER
Gronemeyer, Hinrich; Altucci, Lucia; De Lera, Angel; Stunnenberg, Hendrik Gerard.
PCT/IB2008/001887 (pub. 2008/10/23), WO2008125988-56pp .

13.- Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
Gronemeyer, Hinrich; De Lera, Angel; Altucci, Lucia.
Eur. Pat. Appl. 07290253.9 (published 2008/09/03, Bulletin 2008/36), EP1964835A1-32pp .

12- Expedient Total Syntheses of WIN 64745 and WIN 64821
Carlos Pérez-Balado and Angel R. de Lera
Org Lett. 2008 Sep 4;10(17):3701-4.

11.- New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Susana Álvarez, Yolanda Pazos-Randulfe, Harshal Khanwalkar, Pierre Germain, Rosana Álvarez, Hinrich Gronemeyer, and ángel R. de Lera.
Bioorg Med Chem. 2008 Nov 15;16(22):9719-28.

10.- Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
BelénVaz, Raquél Pereira, Martín Pérez, Rosana Álvarez, Angel R de Lera.
J. Org. Chem., 2008, 73(17), 6534-6541.

9.- Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
Virginie Nahoum, Alexandra Lipski, Fabien Quillard, Jean-François Guichou, Yvan Boublik, Efrén Pérez, Pierre Germain, Angel R. de Lera, and William Bourguet
Acta Cryst. Sect. F , 2008, F64, 614-616.

8.- Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
Paula Lorenzo, Rosana Alvarez, Maria A. Ortiz, Susana Alvarez, F. Javier Piedrafita and Angel R. de Lera
J. Med. Chem., 51 (17), 5431–5440, 2008.

7.- The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway.
Rosana Álvarez, Martín Pérez, Olalla Nieto Faza and Angel R. de Lera.
Organometallics, 27 (14), 3378–3389, 2008.

6.- Synthesis of Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
José A. Souto, Mariarosaria Conte, Rosana Álvarez, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, and Angel R. de Lera
ChemMedChem, Volume 3 Issue 9, Pages 1435 - 1442, 2008.

5.- Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
Anna Druzhko , Rosana Álvarez and Angel R. de Lera
J. Biomater. Sci. Polymer Edn, Vol. 19, No. 12, pp. 1585-1595 (2008)

4.- Retinoic acid analogues inhibit Human Herpesvirus 8 replication. http://www.intmedpress.com/serveFile.cfm?sUID=2b43af61-e6a7-486a-b572-d68d3f72a9d8
Elisabetta Caselli, Galvan Monica, Fabio Santoni, Susana Alvarez, Angel R. de Lera, Diana Ivanova, Hinrich Gronemeyer, Arnaldo Caruso, Massimo Guidoboni, Enzo Cassai, Riccardo Dolcetti, and Dario Di Luca
Antiviral Therapy 2008, 13(2): 199-209

3.- Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids.
Alexander R. Moise, Marta Domínguez, Susana Alvarez, Rosana Alvarez, Michael Schupp, Ana G. Cristancho, Philip D. Kiser, Angel R. de Lera, Mitchell A. Lazar, Krzysztof Palczewski
J. Am. Chem. Soc., 2008, 130(4), 1154-1155.

2.- Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction.
Silva Lopez, Carlos; Nieto Faza, Olalla; de Lera, Angel R..
Journal of Organic Chemistry (2008), 73(2), 467-473.

1.- Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives.
Silva Lopez, Carlos; Perez-Balado, Carlos; Rodriguez-Grana, Paula; de Lera, Angel R..
Organic Letters, 10 (1), 77 -80, 2008.

(TOP)   2007

18.- Structural basis for the high all-trans retinaldehydr reductase activity of the tumor marker AKR1B10
Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita and Xavier Parés
Proceedings of the National Academy of Sciences of the United States of America, (2007), 104(52), 20764

17.- Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum, Virginie; Perez, Efren; Germain, Pierre; Rodriguez-Barrios, Fatima; Manzo, Fabio; Kammerer, Sabrina; Lemaire, Geraldine; Hirsch, Oliver; Royer, Catherine A.; Gronemeyer, Hinrich; de Lera, Angel R.; Bourguet, William.
Proceedings of the National Academy of Sciences of the United States of America (2007), 104(44), 17323-17328.

16.- Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD.
Yan, Xuguang; Perez, Efren; Leid, Mark; Schimerlik, Michael I.; De Lera, Angel R.; Deinzer, Max L.
Protein Science (2007), 16(11), 2491-2501.

15.- Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.
Masia, Susana; Alvarez, Susana; de Lera, Angel R.; Barettino, Domingo.
Molecular Endocrinology (2007), 21(10), 2391-2402.

14.- RAR and RXR modulation in cancer and metabolic disease.
Altucci, Lucia; Leibowitz, Mark D.; Ogilvie, Kathleen M.; de Lera, Angel R.; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 793-810.

13.- Design of selective nuclear receptor modulators: RAR and RXR as a case study.
de Lera, Angel R.; Bourguet, William; Altucci, Lucia; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 811-820.

12.- Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.
Bontempo, Paola; Mita, Luigi; Miceli, Marco; Doto, Antonella; Nebbioso, Angela; De Bellis, Floriana; Conte, Mariarosaria; Minichiello, Annunziata; Manzo, Fabio; Carafa, Vincenzo; Basile, Adriana; Rigano, Daniela; Sorbo, Sergio; Castaldo Cobianchi, Rosa; Schiavone, Ettore Mariano; Ferrara, Felicetto; De Simone, Mariacarla; Vietri, MariaTeresa; Cioffi, Michele; Sica, Vincenzo; Bresciani, Francesco; de Lera, Angel R.; Altucci, Lucia; Molinari, Anna Maria.
International Journal of Biochemistry & Cell Biology (2007), 39(10), 1902-1914.

11.- Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
Alvarez, Susana; Germain, Pierre; Alvarez, Rosana; Rodriguez-Barrios, Fatima; Gronemeyer, Hinrich; De Lera, Angel R..
International Journal of Biochemistry & Cell Biology (2007), 39(7-8), 1406-1415.

10.- Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest.
Lopez, Carlo Silva; Faza, Olalla Nieto; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(17), 5009-5017.

9.- A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents.
Alvarez, Rosana; Faza, Olalla Nieto; de Lera, Angel R.; Cardenas, Diego J.
Advanced Synthesis & Catalysis (2007), 349(6), 887-906.

8.- Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism.
Lopez, Carlos Silva; Faza, Olalla Nieto; Souto, Jose A.; Alvarez, Rosana; De Lera, Angel R..
Journal of Computational Chemistry (2007), 28(8), 1411-1416.

7.- Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study.
Alvarez, Rosana; De Lera, Angel R.; Aurrecoechea, Jose M.; Durana, Aritz.
Organometallics (2007), 26(11), 2799-2802.

6.- Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities.
Perez-Balado, Carlos; Nebbioso, Angela; Rodriguez-Grana, Paula; Minichiello, Annunziata; Miceli, Marco; Altucci, Lucia; de Lera, Angel R..
Journal of Medicinal Chemistry (2007), 50(10), 2497-2505.

5.- Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof.
De Lera, Angel Rodriguez; Otero Cabredo, Maria Paz.
PCT Int. Appl. (2007), 63pp. WO2007029121 A2 20070315

4.- Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study.
Faza, Olalla Nieto; Lopez, Carlos Silva; de Lera, Angel R..
Journal of Organic Chemistry (2007), 72(7), 2617-2624.

3.- Total synthesis of peridinin and related C37-norcarotenoid butenolides.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(4), 1273-1290.

2.- Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions.
De Lera, Angel Rodriguez; Otero, Cabredo Maria Paz.
Fr. Demande (2007), 56pp. FR2888846 A1 20070126

1.- Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol.
Moise, Alexander R.; Isken, Andrea; Dominguez, Marta; De Lera, Angel R.; Von Lintig, Johannes; Palczewski, Krzysztof.
Biochemistry (2007), 46(7), 1811-1820.

(TOP)   2006

15.- International union of pharmacology. LXIII. Retinoid X receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 750-772.

14.- International union of pharmacology. LX. Retinoic acid receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 712-725.

13.- Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARb /d agonists.
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(24), 4514-4525.

12.- The role of the 11-cis-retinal ring methyl substituents in visual pigment formation.
Dominguez, Marta; Alvarez, Rosana; Perez, Martin; Palczewski, Krzysztof; de Lera, Angel R..
ChemBioChem (2006), 7(11), 1815-1825.

11.- A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation.
Bosch, Laia; Cordomi, Arnau; Dominguez, Marta; Toledo, Darwin; Morillo, Margarita; Perez, Juan J.; Alvarez, Rosana; de Lera, Angel R.; Garriga, Pere.
Vision Research (2006), 46(27), 4472-4481.

10.- Activity of alcohol dehydrogenase with 11-cis-retinoids and distribution of ADH4 in ocular tissues.
Porte, Sergio; Martras, Silvia; Martinez, Susana E.; Alvarez, Rosana; Gallego, Oriol; Dominguez, Marta; Duester, Gregg; de Lera, Angel R.; Farres, Jaume; Pares, Xavier.
Enzymology and Molecular Biology of Carbonyl Metabolism--12, [International Meeting], 12th, Burlington, VT, United States, July 6-11, 2004 (2006), Meeting Date 2004, 200-207.

9.- The Stille Reaction in the Synthesis of the C37-Norcarotenoid Butenolide Pyrrhoxanthin. Scope and Limitations.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(16), 5914-5920.

8.- Cycloisomerization of Activated (2E,4Z)-Heptatrienoate and Its Relevance to Crispatene (Bio)synthesis. A Case of Concerted and Stepwise Uncertainty.
Lopez, Carlos Silva; Faza, Olalla Nieto; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(12), 4497-4501.

7.- Computational Study and Analysis of the Kinetic Isotope Effects of the Rearrangement of cis-Bicyclo[4.2.0]oct-7-ene to cis,cis-Cycloocta-1,3-diene.
Silva Lopez, Carlos; Nieto Faza, Olalla; De Lera, Angel R..
Organic Letters (2006), 8(10), 2055-2058.

6.- Natural and synthetic retinoids: structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors.
Dolcetti, Riccardo; Di Luca, Dario; de Lera, Angel R..
Anti-Infective Agents in Medicinal Chemistry (2006), 5(1), 85-103.

5.- Mechanism of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: A Center-to-Helix-to-Center Chirality Transfer.
Nieto Faza, Olalla; Silva Lopez, Carlos; Alvarez, Rosana; De Lera, Angel R..
Journal of the American Chemical Society (2006), 128(7), 2434-2437.

4.- Computation of vertical excitation energies of retinal and analogs: Scope and limitations.
Lopez, Carlos Silva; Faza, Olalla Nieto; Estevez, Susana Lopez; De Lera, Angel R..
Journal of Computational Chemistry (2006), 27(1), 116-123.

3.- Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis.
Dominguez, Marta; Alvarez, Rosana; Borras, Emma; Farres, Jaume; Pares, Xavier; De Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(1), 155-164.

2.- Computational Characterization of a Complete Palladium-Catalyzed Cross-Coupling Process: The Associative Transmetalation in the Stille Reaction.
Alvarez, Rosana; Nieto Faza, Olalla; Silva Lopez, Carlos; de Lera, Angel R..
Organic Letters (2006), 8(1), 35-38.

1.- Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Bioorganic and Medicinal Chemistry Letters (2006), 16(1), 49-54.

(TOP)   2005

14.- Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Chem. Commun. 2005, 4285-4287

13.- Synthesis of N-heteroaryl Retinoids and Their Artificial Bacteriorhodopsins
Susana López, Virginia Rodríguez, Javier Montenegro, Carlos Saá Rosana Álvarez, Carlos Silva, Angel R. de Lera, Rosana Simón, Tzvetana Lazarova and Esteve Padrós
ChemBioChem 2005, 6, 2078-2087

12.- Ligand Recognition by RAR and RXR Receptors: Binding and Selectivity
Fredy Sussman and Angel R. de Lera
J. Med. Chem. 2005, 48, 6212-6219

11.- 2-Alkylidenesulfol-3-enes by (Regio and) Stereoselective Cheletropic Addition of SO₂ to (Di)vinylallenes
José A. Souto, Carlos Silva, Olalla Nieto Rosana Alvarez and Angel R. de Lera
Org. Lett. 2005, 7, 1565-1568

10.- Simple Diastereoselectivity of the BF₃·OEt₂-Catalyzed Vinylogous Mukaiyama Aldol Reaction of 2-(Trimethylsiloxy)furans with Aldehydes
Carlos Silva, Rosana Alvarez, Belén Vaz, Olalla Nieto and Angel R. de Lera
J. Org. Chem. 2005, 70, 3654-3659

9.- Design and Synthesis of RXR Modulators
Angel R. de Lera
Actualités de Chimie Thérapeutique, 2005, 31, 21-45

8.- 14-Fluoro-Bacteriorhodopsin Gelation Films for Dynamic Holography Recording
Elena Korchemskaya, Nicolai Burykin, Angel R. de Lera, Rosana Alvarez, Sergey Pirutin and Anna B. Druzhko
Photochemistry and Photobiology, Volume 81 Issue 4, Pages 920 - 923

7.- Tumor-selective action of HDAC Inhibitors involves TRAIL induction in acute myeloid leukemia cells
Angela Nebossio, Nicole Clarke, Paola Bontempo, Emilie Volz, Rosana Alvarez, Ettore M. Schiavone, Alexssandro Weisz, Francesco Bresciani, Angel R. de Lera, Hinrich Gronemeyer and Lucia Altucci
Nature Medicine 2005, 11, 77-84

6.- Effect of Dehydration on Photoinduced Transformation in Gelatin Films Made of WT and D96N 14-Fluoro-bacteriorhodopsin
Anna B. Druzhko, Sergey K. Pirutin, Angel R. de Lera, Rosana Alvarez and Howard, H. Weetall
Appl. Biochem. Biotechnol. 2005, 120, 121-132

5.- The Stille Reaction in the Synthesis of Carotenoid Butenolides: Synthesis of 6'-epi-Peridinin
Belén Vaz, Rosana Alvarez, Reinhard Brückner and Angel R. de Lera
Org. Lett. 2005, 7, 545-548

4.- γ-Allenyl Allyl Benzothiazole Sulfonyl Anions Undergo cis-Selective (Sylvestre) Julia Olefinations
Belén Vaz, José A. Souto, Rosana Alvarez and Angel R. de Lera
Synlett. 2005, 294-298

3.- Characterization of the Interaction between Retinoic Acid Receptor/Retinoid X Receptor (RAR/RXR) Heterodimers and Transcriptional Coactivators through Structural and Fluorescence Anisotropy Studies
Vivian Pogenberg, Jean-François Guichou, Valie Vivat-Hannah, Sabrina Kammerer, Efrén Pérez, Pierre Germain, Angel R. de Lera, Hinrich Gronemeyer, Catherine A. Royer and William Bourguet
J. Biol. Chem. 2005, 280, 1625-1633

2.- Ellipticity: A Convenient Tool to Characterize Electrocyclic Reactions
Carlos Silva, Olalla Nieto, Fernando P. Cossío, Darrin M. York and Angel R. de Lera
Chemistry: Eur. J. 2005, 11, 1734-1738

1.- Pseudorotation Barriers of Biological Oxyphosphoranes: A Challenge for Simulations of Ribozyme Catalysis
Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
Chemistry: Eur. J. 2005, 11, 2081-2093

(TOP)   2004

13.- The Specicifity of Alcohol Dehydrogenase With cis-Retinoids.
Silvia Martras, Rosana Alvarez, Susana E. Martínez, Dámaso Torres, Oriol Gallego, Gregg Duester, Jaume Farrés, Angel R. de Lera and Xavier Parés
Eur. J. Biochem. 2004, 271, 1660-1670

12.- 14-Fluorobacteriorhodopsin gelatin films: performance at different relative humidities
A. B. Druzhko, S. K. Pirutin, A. R. de Lera, R. Alvarez, S. Alvarez and M. Domínguez
J. Biol. Phys. Chem. 2004, 4, 11-16.

11.- Enantioselective Synthesis of all of the Stereoisomers of (E)-13,14-Dihydroxyretinol (DHR)
Susana Alvarez, Rosana Alvarez and Angel R. de Lera
Tetrahedron:Asymmetry 2004, 15, 839-846

10.- Conrotatory Ring Opening Reactions of Cyclopropyl Anions in Monocyclic and Tricyclic Systems
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Org. Lett. 2004, 6, 901-904

9.- The Woodward-Hoffmann-DePuy rule revisited
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Org. Lett. 2004, 6, 905-908

8.- Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis
Carlos Silva, Olalla Nieto, Brent A. Gregersen, X. López, Angel R. de Lera and D. M. York
Chem. Phys. Chem. 2004, 5, 1045-1049

7.- Theoretical Study of the Vinyl Allene Oxide to Cyclopent-2-en-1-one Rearrangement: Mechanism, Torquoselectivity and Solvent Effects
Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
J. Org. Chem. 2004, 69, 3635-3644

6.- Theoretical Study of the Electrocyclic Ring Closure of Hydroxypentadienyl Cations
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Chem. Eur. J. 2004, 10, 4324-4333

5.- Rational design of RAR selective agonists revealed by RAR-β crystal structure
Pierre Gemain, Sabrina Kammerer, Efrén Pérez, Carole Peluso-Iltis, David Tortolani, F. Cristopher Zusi, John Starrett, Philippe Lapointe, Jean-Paull Daris, Anne Marinier, Angel R. de Lera, Natasha Rochel, Hinrich Gronemeyer
EMBO Rep. 2004, 5, 877-882

4.- Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80.
Silvia Martras, Rosana Alvarez, Oriol Gallego, Marta Domínguez, Angel R. de Lera, Jaume Farrés and Xavier Parés
Arch. Biochem. Biophys. 2004, 430, 210-217

3.- 9-cis Retinoic Acid Analogues With Bulky Hydrophobic Rings: New RXR-Selective Agonists
Rosana Alvarez, M. Jess Vega, Sabrina Kammerer, Aurèlie Rossin, Pierre Germain, Hinrich Gronemeyer and Angel R. de Lera
Bioorg. Med. Chem. Lett. 2004, 14, 6117-6122

2.- Synthesis of Ring-oxidized Retinoids as Substrates of Mouse Class I Alcohol Dehydrogenase (ADH1)
Marta Domínguez, Rosana Alvarez, Silvia Martras, Jaume Farré, Xavier Parés and Angel R. de Lera
Org. Biomol. Chem. 2004, 2, 3368-3373

1.- Solvolytic Ring Opening Reactions of Cyclopropyl Halides. An Assessment of the Woodward-Hoffmann-DePuy Rule
Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
J. Org. Chem. 2004, 69, 9002-9010

(TOP)   2003

Recent Advances in the Synthesis of Retinoids
Beatriz Domínguez, Rosana Alvarez and Angel R. de Lera
Org. Prep. Proc. Int. 2003, 35, 239-306

9Z- and 11Z-8-Methylretinals for Artificial Visual Pigment Studies. Stereoselective Synthesis, Structure and Binding Modeling
Rosana Alvarez, Marta Domínguez, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
Chem. Eur. J., 2003, 9, 5821-5831

(TOP)   2002

Bleaching kinetics of artificial visual pigments with modifications near the ring/polyene chain connection
Istvan Szundi, Angel R. de Lera, Yolanda Pazos, Rosana Alvarez, Marco Oliana, Mordechai Sheves, James W. Lewis and David S. Kliger
Biochemistry 2002, 41, 2028-2035

Reply to:
Electrocyclization of (Z)-1,2,4,6-Heptatetraene and Its Heterosubstituted Analogs: Pericyclic or Pseudopericyclic?
Angel R. de Lera and Fernando P. Cossío
Angew. Chem. Int. Ed. 2002,41, 1150-1152

Synthesis of Symmetrical Carotenoids by a Two-fold Stille Coupling
Belén Vaz, Rosana Alvarez and Angel R. de Lera
J. Org. Chem. 2002, 67, 5040-5043

Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor
M. Paz Otero, Alicia Torrado, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
J. Org. Chem. 2002, 67, 5876-5882

Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
Beatriz Domínguez, M. Jesús Vega, Fredy Sussman and Angel R. de Lera
Bioorg. Med. Chem. Lett. 2002, 12, 2607-2609

(TOP)   2001

Photoinduced Transformation of 14-F-Bacteriorhodopsin Gelatin Films Based on Both Wild Type and D96N Mutants
Anna B. Druzhko, V.Y. Shakhbazian, Rosana Alvarez, Angel R. de Lera and Howard H. Weetall
Biosystems 2001, 59, 53-60

An Expedient Stereocontrolled Synthesis of 7-cis-Retinoids
Rosana Alvarez, Beatriz Domínguez and Angel R. de Lera
Synth. Commun. 2001, 31, 2083-2087

On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4,5-trienals and their Schiff Bases
Angel R. de Lera, Rosana Alvarez, Begoña Lecea, Alicia Torrado and Fernando P. Cossío
Angew. Chem. Int. Ed. 2001, 40, 557-561

A General Synthesis of Alkylpyridines
Beatriz Iglesias, Rosana Alvarez and Angel R. de Lera
Tetrahedron 2001, 57, 3125-3130

Regioselective palladium-catalyzed cross-coupling reactions in the synthesis of novel 2,3-disubstituted thiophene derivatives
Raquel Pereira, Beatriz Iglesias and Angel R. de Lera
Tetrahedron 2001, 57, 7871-7881

Suzuki cross-coupling of meso-dibromoporphyrins for the synthesis of functionalized A₂B₂ porphyrins
Belén Vaz, Rosana Alvarez, Mar Nieto, Antonio I. Paniello and Angel R. de Lera
Tetrahedron Lett. 2001, 42, 7409-7412

The Suzuki Coupling Reaction in the Stereocontrolled Synthesis of 9-cis-Retinoic Acid and Its Ring-Demethylated Analogues
Yolanda Pazos, Beatriz Iglesias and Angel R. de Lera
J. Org. Chem. 2001, 66, 8483-8489

(TOP)   2000

A Pericyclic Cascade to the Stereocontrolled Synthesis of 9-cis-Retinoids
Beatriz Iglesias, Alicia Torrado, and Angel R. de Lera
J. Org. Chem. 2000, 65, 2696-2705

Measurement of Proton Release and Uptake by Analogs of Bacteriorhodopsin
Howard H. Weetall , Anna B. Druzhko, Angel R. de Lera, Rosana Alvarez and Baldwin Robertson
Bioelectrochemistry, 2000, 51, 27-33

Torquoselectivity in the Cationic Cyclopentannelation of (2Z)-Hexa-2,4,5-trienal Acetals
Angel R. de Lera, Beatriz Iglesias, Susana López and Jesús Rodríguez
Chem. Eur. J., 2000, 6, 4021-4033

Stereocontrolled Synthesis of 6-s-cis- and 6-s-trans-Locked 9Z-Retinoids by Hydroxyl-Accelerated Stille Coupling of (Z)-Tri-n-Butylstannylbut-2-en-1-ol and Bicyclic Dienyl Triflates
Beatriz Domínguez, Yolanda Pazos and Angel R. de Lera
J. Org. Chem. 2000, 65, 5917-5925

Isomerization of all-trans-Retinol to cis-Retinols in Bovine Retinal Pigment Epithelial Cells: Dependence on the Specificity of Retinoid-Binding Proteins
J. K. McBee, V. Kuksa, R. Alvarez, Angel R. de Lera, O. Prezhdo, F. Haeseleer, I. Sokal and K. Palczewski
Biochemistry 2000, 39, 11370-11380