Publications
2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
2009
Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers.
Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
J. Med. Chem. 2009, 52(10), 3150–3158.
Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists.
Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2009, 17(13), 4345-4359.
Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
ChemMedChem, 2009, 4(5), 780-791.
Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera.
ChemBioChem, 2009, 10(7), 1252-1259.
Mechanism of the Gold-Catalyzed Rearrangement of (3-Acyloxyprop-1-ynyl)oxiranes: A Dual Role of the Catalyst
Adán González Pérez, Carlos Silva López, José Marco-Contelles, Olalla Nieto Faza, Elena Soriano, and Angel R. de Lera
J. Org. Chem., 2009, 74(9), 2982–2991.
Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
Chem. Eur. J. 2009, 15(8), 1944 - 1956
The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment.
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
J. Am. Chem. Soc. 2009, 131(10), 3650-3657
Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana.
Org Lett 2009, 11 (5), pp 1083–1086
Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels.
Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
Chemico-Biological Interactions 2009, 178(1-3) 171–177
Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin.
Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga.
Photochemistry and Photobiology 2009, 85(2) March/April, 485-493
Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
European Journal of Medicinal Chemistry, 2009, in press, online 1-13
Efrén Pérez Santín, Pierre Germain, Fabien Quillard, Harshal Khanwalkar, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera and William Bourguet
J. Med. Chem. 2009, 52(10), 3150–3158.
Retinoid Receptor Subtype-Selective Modulators Through Synthetic Modifications of RARγ Agonists.
Susana Álvarez, Rosana Álvarez, Harshal Khanwalkar, Pierre Germain, Géraldine Lemaire, Fátima Rodríguez-Barrios, Hinrich Gronemeyer, Ángel R. de Lera
Bioorganic & Medicinal Chemistry, 2009, 17(13), 4345-4359.
Highly Potent Naphthofuran-Based Retinoic Acid Receptor Agonists
Efrén Pérez Santín, Harshal Khanwalkar, Johannes Voegel, Pascal Collette, Pascale Mauvais, Hinrich Gronemeyer, Ángel R. de Lera
ChemMedChem, 2009, 4(5), 780-791.
Pyrazine Arotinoids with Inverse Agonist Activities on the Retinoid and Rexinoid Receptors
José García, Harshal Khanwalkar, Raquel Pereira, Cathie Erb, Johannes J. Voegel, Pascal Collette, Pascale Mauvais, William Bourguet, Hinrich Gronemeyer, Ángel R. de Lera.
ChemBioChem, 2009, 10(7), 1252-1259.
Mechanism of the Gold-Catalyzed Rearrangement of (3-Acyloxyprop-1-ynyl)oxiranes: A Dual Role of the Catalyst
Adán González Pérez, Carlos Silva López, José Marco-Contelles, Olalla Nieto Faza, Elena Soriano, and Angel R. de Lera
J. Org. Chem., 2009, 74(9), 2982–2991.
Regio-, Peri-, and Torquoselectivity in Hydroxy Heptatrienyl Cation Electrocyclizations: The Iso/Homo-Nazarov Reaction
Olalla Nieto Faza, Carlos Silva López, Rosana álvarez, and ángel R. de Lera
Chem. Eur. J. 2009, 15(8), 1944 - 1956
The C-C Reductive Elimination in Palladium Complexes, and the Role of Coupling Additives. A DFT Study Supported by Experiment.
Martín Pérez-Rodríguez, Ataualpa A. C. Braga, Max Garcia-Melchor, Mónica H. Pérez-Temprano, Juan A. Casares,Gregori Ujaque, Angel R. de Lera,Rosana álvarez, Feliu Maseras and Pablo Espinet
J. Am. Chem. Soc. 2009, 131(10), 3650-3657
Palladium-Catalyzed Sequential Oxidative Cyclization/Coupling of 2-Alkynylphenols and Alkenes: A Direct Entry into 3-Alkenylbenzofurans"
Martínez, Claudio; Aurrecoechea, José; álvarez, Rosana.
Org Lett 2009, 11 (5), pp 1083–1086
Aldo-keto reductases from the AKR1B subfamily: Retinoid specificity and control of cellular retinoic acid levels.
Xavier Ruiz; Oriol Gallego.; Albert Ardèvol.; Armando Moro.; Marta Domínguez.; Susana Alvarez.; Rosana Alvarez.; Angel R de Lera.; Carme Rovira.; Ignacio Fita.; Xavier Parés.; Jaume Farrés
Chemico-Biological Interactions 2009, 178(1-3) 171–177
Structural Coupling of 11-cis-7-Methyl-retinal and Amino Acids at the Ligand Binding Pocket of Rhodopsin.
Mònica Aguilà, Darwin Toledo, Margarita Morillo, Marta Dominguez, Belén Vaz, Rosana Alvarez, Angel R. de Lera, Pere Garriga.
Photochemistry and Photobiology 2009, 85(2) March/April, 485-493
Highly Twisted Adamantyl Arotinoids: Synthesis, Antiproliferative Effects and RXR Transactivation Profiles
Santiago Pérez-Rodríguez, Maria A. Ortiz, Raquel Pereira, Fátima Rodríguez-Barrios, Angel R. de Lera and F. Javier Piedrafita
European Journal of Medicinal Chemistry, 2009, in press, online 1-13
2008
NOVEL DERIVATIVES OF PSAMMAPLIN A, A METHOD FOR THEIR SYNTHESIS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF CANCER
Gronemeyer, Hinrich; Altucci, Lucia; De Lera, Angel; Stunnenberg, Hendrik Gerard.
PCT/IB2008/001887 (pub. 2008/10/23), WO2008125988-56pp .
Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
Gronemeyer, Hinrich; De Lera, Angel; Altucci, Lucia.
Eur. Pat. Appl. 07290253.9 (published 2008/09/03, Bulletin 2008/36), EP1964835A1-32pp .
Expedient Total Syntheses of WIN 64745 and WIN 64821
Carlos Pérez-Balado and Angel R. de Lera
Org Lett. 2008 Sep 4;10(17):3701-4.
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Susana Álvarez, Yolanda Pazos-Randulfe, Harshal Khanwalkar, Pierre Germain, Rosana Álvarez, Hinrich Gronemeyer, and ángel R. de Lera.
Bioorg Med Chem. 2008 Nov 15;16(22):9719-28.
Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
BelénVaz, Raquél Pereira, Martín Pérez, Rosana Álvarez, Angel R de Lera.
J. Org. Chem., 2008, 73(17), 6534-6541.
Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
Virginie Nahoum, Alexandra Lipski, Fabien Quillard, Jean-François Guichou, Yvan Boublik, Efrén Pérez, Pierre Germain, Angel R. de Lera, and William Bourguet
Acta Cryst. Sect. F , 2008, F64, 614-616.
Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
Paula Lorenzo, Rosana Alvarez, Maria A. Ortiz, Susana Alvarez, F. Javier Piedrafita and Angel R. de Lera
J. Med. Chem., 51 (17), 5431–5440, 2008.
The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway.
Rosana Álvarez, Martín Pérez, Olalla Nieto Faza and Angel R. de Lera.
Organometallics, 27 (14), 3378–3389, 2008.
Synthesis of Novel Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
José A. Souto, Mariarosaria Conte, Rosana Álvarez, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, and Angel R. de Lera
ChemMedChem, Volume 3 Issue 9, Pages 1435 - 1442, 2008.
Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
J. Nutrit. Biochem., 2008, Available online 6 November 2008, xx (2008) xxx–xxx
Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
Anna Druzhko , Rosana Álvarez and Angel R. de Lera
J. Biomater. Sci. Polymer Edn, Vol. 19, No. 12, pp. 1585-1595 (2008)
Retinoic acid inhibits Human Herpesvirus 8 replication.
Elisabetta Caselli, Galvan Monica, Fabio Santoni, Susana Alvarez, Angel R. de Lera, Diana Ivanova, Hinrich Gronemeyer, Arnaldo Caruso, Massimo Guidoboni, Enzo Cassai, Riccardo Dolcetti, and Dario Di Luca
Antiviral Therapy 2008, 13(2): 199-209
Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids.
Alexander R. Moise, Marta Domínguez, Susana Alvarez, Rosana Alvarez, Michael Schupp, Ana G. Cristancho, Philip D. Kiser, Angel R. de Lera, Mitchell A. Lazar, Krzysztof Palczewski
J. Am. Chem. Soc., 2008, 130(4), 1154-1155.
Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction.
Silva Lopez, Carlos; Nieto Faza, Olalla; de Lera, Angel R..
Journal of Organic Chemistry (2008), 73(2), 467-473.
Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives.
Silva Lopez, Carlos; Perez-Balado, Carlos; Rodriguez-Grana, Paula; de Lera, Angel R..
Organic Letters, 10 (1), 77 -80, 2008.
Top
Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita and Xavier Parés
Proceedings of the National Academy of Sciences of the United States of America, (2007), 104(52), 20764
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum, Virginie; Perez, Efren; Germain, Pierre; Rodriguez-Barrios, Fatima; Manzo, Fabio; Kammerer, Sabrina; Lemaire, Geraldine; Hirsch, Oliver; Royer, Catherine A.; Gronemeyer, Hinrich; de Lera, Angel R.; Bourguet, William.
Proceedings of the National Academy of Sciences of the United States of America (2007), 104(44), 17323-17328.
Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD.
Yan, Xuguang; Perez, Efren; Leid, Mark; Schimerlik, Michael I.; De Lera, Angel R.; Deinzer, Max L.
Protein Science (2007), 16(11), 2491-2501.
Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.
Masia, Susana; Alvarez, Susana; de Lera, Angel R.; Barettino, Domingo.
Molecular Endocrinology (2007), 21(10), 2391-2402.
RAR and RXR modulation in cancer and metabolic disease.
Altucci, Lucia; Leibowitz, Mark D.; Ogilvie, Kathleen M.; de Lera, Angel R.; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 793-810.
Design of selective nuclear receptor modulators: RAR and RXR as a case study.
de Lera, Angel R.; Bourguet, William; Altucci, Lucia; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 811-820.
Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.
Bontempo, Paola; Mita, Luigi; Miceli, Marco; Doto, Antonella; Nebbioso, Angela; De Bellis, Floriana; Conte, Mariarosaria; Minichiello, Annunziata; Manzo, Fabio; Carafa, Vincenzo; Basile, Adriana; Rigano, Daniela; Sorbo, Sergio; Castaldo Cobianchi, Rosa; Schiavone, Ettore Mariano; Ferrara, Felicetto; De Simone, Mariacarla; Vietri, MariaTeresa; Cioffi, Michele; Sica, Vincenzo; Bresciani, Francesco; de Lera, Angel R.; Altucci, Lucia; Molinari, Anna Maria.
International Journal of Biochemistry & Cell Biology (2007), 39(10), 1902-1914.
Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
Alvarez, Susana; Germain, Pierre; Alvarez, Rosana; Rodriguez-Barrios, Fatima; Gronemeyer, Hinrich; De Lera, Angel R..
International Journal of Biochemistry & Cell Biology (2007), 39(7-8), 1406-1415.
Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest.
Lopez, Carlo Silva; Faza, Olalla Nieto; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(17), 5009-5017.
A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents.
Alvarez, Rosana; Faza, Olalla Nieto; de Lera, Angel R.; Cardenas, Diego J.
Advanced Synthesis & Catalysis (2007), 349(6), 887-906.
Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism.
Lopez, Carlos Silva; Faza, Olalla Nieto; Souto, Jose A.; Alvarez, Rosana; De Lera, Angel R..
Journal of Computational Chemistry (2007), 28(8), 1411-1416.
Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study.
Alvarez, Rosana; De Lera, Angel R.; Aurrecoechea, Jose M.; Durana, Aritz.
Organometallics (2007), 26(11), 2799-2802.
Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities.
Perez-Balado, Carlos; Nebbioso, Angela; Rodriguez-Grana, Paula; Minichiello, Annunziata; Miceli, Marco; Altucci, Lucia; de Lera, Angel R..
Journal of Medicinal Chemistry (2007), 50(10), 2497-2505.
Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof.
De Lera, Angel Rodriguez; Otero Cabredo, Maria Paz.
PCT Int. Appl. (2007), 63pp. WO2007029121 A2 20070315
Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study.
Faza, Olalla Nieto; Lopez, Carlos Silva; de Lera, Angel R..
Journal of Organic Chemistry (2007), 72(7), 2617-2624.
Total synthesis of peridinin and related C37-norcarotenoid butenolides.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(4), 1273-1290.
Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions.
De Lera, Angel Rodriguez; Otero, Cabredo Maria Paz.
Fr. Demande (2007), 56pp. FR2888846 A1 20070126
Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol.
Moise, Alexander R.; Isken, Andrea; Dominguez, Marta; De Lera, Angel R.; Von Lintig, Johannes; Palczewski, Krzysztof.
Biochemistry (2007), 46(7), 1811-1820.
Gronemeyer, Hinrich; Altucci, Lucia; De Lera, Angel; Stunnenberg, Hendrik Gerard.
PCT/IB2008/001887 (pub. 2008/10/23), WO2008125988-56pp .
Derivatives of psammaplin A, a method for their synthesis and their use for the prevention or treatment of cancer
Gronemeyer, Hinrich; De Lera, Angel; Altucci, Lucia.
Eur. Pat. Appl. 07290253.9 (published 2008/09/03, Bulletin 2008/36), EP1964835A1-32pp .
Expedient Total Syntheses of WIN 64745 and WIN 64821
Carlos Pérez-Balado and Angel R. de Lera
Org Lett. 2008 Sep 4;10(17):3701-4.
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Susana Álvarez, Yolanda Pazos-Randulfe, Harshal Khanwalkar, Pierre Germain, Rosana Álvarez, Hinrich Gronemeyer, and ángel R. de Lera.
Bioorg Med Chem. 2008 Nov 15;16(22):9719-28.
Stereoselective Stille Coupling of Enantiopure Haloallenes and Alkenylstannanes for the Synthesis of Allenyl Carotenoids. Experimental and Computational Studies
BelénVaz, Raquél Pereira, Martín Pérez, Rosana Álvarez, Angel R de Lera.
J. Org. Chem., 2008, 73(17), 6534-6541.
Nuclear receptor ligand binding domains: reduction of helix H12 dynamics to favor crystallization
Virginie Nahoum, Alexandra Lipski, Fabien Quillard, Jean-François Guichou, Yvan Boublik, Efrén Pérez, Pierre Germain, Angel R. de Lera, and William Bourguet
Acta Cryst. Sect. F , 2008, F64, 614-616.
Inhibition of IκB Kinaseβ and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids
Paula Lorenzo, Rosana Alvarez, Maria A. Ortiz, Susana Alvarez, F. Javier Piedrafita and Angel R. de Lera
J. Med. Chem., 51 (17), 5431–5440, 2008.
The Associative Transmetalation in the Stille Cross-Coupling Reaction to Form Dienes: Theoretical Insights into the Open Pathway.
Rosana Álvarez, Martín Pérez, Olalla Nieto Faza and Angel R. de Lera.
Organometallics, 27 (14), 3378–3389, 2008.
Synthesis of Novel Benzamides Related to Anacardic Acid and Their Histone Acetyltransferase (HAT) Inhibitory Activities
José A. Souto, Mariarosaria Conte, Rosana Álvarez, Angela Nebbioso, Vincenzo Carafa, Lucia Altucci, and Angel R. de Lera
ChemMedChem, Volume 3 Issue 9, Pages 1435 - 1442, 2008.
Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7
Yunkyoung Lee, Jerry T. Thompson, Angel R. de Lera and John P. Vanden Heuvel
J. Nutrit. Biochem., 2008, Available online 6 November 2008, xx (2008) xxx–xxx
Photochromic polymer films based on a 14-F bacteriorhodopsin derivative
Anna Druzhko , Rosana Álvarez and Angel R. de Lera
J. Biomater. Sci. Polymer Edn, Vol. 19, No. 12, pp. 1585-1595 (2008)
Retinoic acid inhibits Human Herpesvirus 8 replication.
Elisabetta Caselli, Galvan Monica, Fabio Santoni, Susana Alvarez, Angel R. de Lera, Diana Ivanova, Hinrich Gronemeyer, Arnaldo Caruso, Massimo Guidoboni, Enzo Cassai, Riccardo Dolcetti, and Dario Di Luca
Antiviral Therapy 2008, 13(2): 199-209
Stereospecificity of Retinol Saturase: Absolute Configuration, Synthesis and Biological Evaluation of Dihydroretinoids.
Alexander R. Moise, Marta Domínguez, Susana Alvarez, Rosana Alvarez, Michael Schupp, Ana G. Cristancho, Philip D. Kiser, Angel R. de Lera, Mitchell A. Lazar, Krzysztof Palczewski
J. Am. Chem. Soc., 2008, 130(4), 1154-1155.
Characterization of the Switch in the Mechanism of an Intramolecular Diels-Alder Reaction.
Silva Lopez, Carlos; Nieto Faza, Olalla; de Lera, Angel R..
Journal of Organic Chemistry (2008), 73(2), 467-473.
Mechanistic Insights into the Stereocontrolled Synthesis of Hexahydropyrrolo[2,3-b]indoles by Electrophilic Activation of Tryptophan Derivatives.
Silva Lopez, Carlos; Perez-Balado, Carlos; Rodriguez-Grana, Paula; de Lera, Angel R..
Organic Letters, 10 (1), 77 -80, 2008.
Top
2007
Structural basis for the high all-trans retinaldehydr reductase activity of the tumor marker AKR1B10Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita and Xavier Parés
Proceedings of the National Academy of Sciences of the United States of America, (2007), 104(52), 20764
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Nahoum, Virginie; Perez, Efren; Germain, Pierre; Rodriguez-Barrios, Fatima; Manzo, Fabio; Kammerer, Sabrina; Lemaire, Geraldine; Hirsch, Oliver; Royer, Catherine A.; Gronemeyer, Hinrich; de Lera, Angel R.; Bourguet, William.
Proceedings of the National Academy of Sciences of the United States of America (2007), 104(44), 17323-17328.
Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRa LBD.
Yan, Xuguang; Perez, Efren; Leid, Mark; Schimerlik, Michael I.; De Lera, Angel R.; Deinzer, Max L.
Protein Science (2007), 16(11), 2491-2501.
Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor.
Masia, Susana; Alvarez, Susana; de Lera, Angel R.; Barettino, Domingo.
Molecular Endocrinology (2007), 21(10), 2391-2402.
RAR and RXR modulation in cancer and metabolic disease.
Altucci, Lucia; Leibowitz, Mark D.; Ogilvie, Kathleen M.; de Lera, Angel R.; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 793-810.
Design of selective nuclear receptor modulators: RAR and RXR as a case study.
de Lera, Angel R.; Bourguet, William; Altucci, Lucia; Gronemeyer, Hinrich.
Nature Reviews Drug Discovery (2007), 6(10), 811-820.
Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.
Bontempo, Paola; Mita, Luigi; Miceli, Marco; Doto, Antonella; Nebbioso, Angela; De Bellis, Floriana; Conte, Mariarosaria; Minichiello, Annunziata; Manzo, Fabio; Carafa, Vincenzo; Basile, Adriana; Rigano, Daniela; Sorbo, Sergio; Castaldo Cobianchi, Rosa; Schiavone, Ettore Mariano; Ferrara, Felicetto; De Simone, Mariacarla; Vietri, MariaTeresa; Cioffi, Michele; Sica, Vincenzo; Bresciani, Francesco; de Lera, Angel R.; Altucci, Lucia; Molinari, Anna Maria.
International Journal of Biochemistry & Cell Biology (2007), 39(10), 1902-1914.
Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
Alvarez, Susana; Germain, Pierre; Alvarez, Rosana; Rodriguez-Barrios, Fatima; Gronemeyer, Hinrich; De Lera, Angel R..
International Journal of Biochemistry & Cell Biology (2007), 39(7-8), 1406-1415.
Electrocyclic ring opening of cis-bicyclo[m.n.0]alkenes: the anti-Woodward-Hoffmann quest.
Lopez, Carlo Silva; Faza, Olalla Nieto; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(17), 5009-5017.
A density functional theory study of the stille cross-coupling via associative transmetalation. The role of ligands and coordinating solvents.
Alvarez, Rosana; Faza, Olalla Nieto; de Lera, Angel R.; Cardenas, Diego J.
Advanced Synthesis & Catalysis (2007), 349(6), 887-906.
Pseudopericyclic design drives antara-antara [1,5] methylene sigmatropic shifts from a stepwise to a concerted mechanism.
Lopez, Carlos Silva; Faza, Olalla Nieto; Souto, Jose A.; Alvarez, Rosana; De Lera, Angel R..
Journal of Computational Chemistry (2007), 28(8), 1411-1416.
Bimetallic Intermediates in the Formation of Nucleophilic Allenylzincs from Allenylpalladiums: A DFT Study.
Alvarez, Rosana; De Lera, Angel R.; Aurrecoechea, Jose M.; Durana, Aritz.
Organometallics (2007), 26(11), 2799-2802.
Bispyridinium Dienes: Histone Deacetylase Inhibitors with Selective Activities.
Perez-Balado, Carlos; Nebbioso, Angela; Rodriguez-Grana, Paula; Minichiello, Annunziata; Miceli, Marco; Altucci, Lucia; de Lera, Angel R..
Journal of Medicinal Chemistry (2007), 50(10), 2497-2505.
Cyclopent-2-en-1-one derivatives as PPAR modulators, their preparation, pharmaceutical and cosmetic compositions, and uses thereof.
De Lera, Angel Rodriguez; Otero Cabredo, Maria Paz.
PCT Int. Appl. (2007), 63pp. WO2007029121 A2 20070315
Sulfoxide-Induced Stereoselection in [1,5]-Sigmatropic Hydrogen Shifts of Vinylallenes. A Computational Study.
Faza, Olalla Nieto; Lopez, Carlos Silva; de Lera, Angel R..
Journal of Organic Chemistry (2007), 72(7), 2617-2624.
Total synthesis of peridinin and related C37-norcarotenoid butenolides.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Chemistry--A European Journal (2007), 13(4), 1273-1290.
Preparation of cyclopent-2-en-1-one derivatives as PPAR modulators and their use in cosmetic and pharmaceutical compositions.
De Lera, Angel Rodriguez; Otero, Cabredo Maria Paz.
Fr. Demande (2007), 56pp. FR2888846 A1 20070126
Specificity of Zebrafish Retinol Saturase: Formation of All-trans-13,14-dihydroretinol and All-trans-7,8-dihydroretinol.
Moise, Alexander R.; Isken, Andrea; Dominguez, Marta; De Lera, Angel R.; Von Lintig, Johannes; Palczewski, Krzysztof.
Biochemistry (2007), 46(7), 1811-1820.
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2006
International union of pharmacology. LXIII. Retinoid X receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 750-772.
International union of pharmacology. LX. Retinoic acid receptors.
Germain, Pierre; Chambon, Pierre; Eichele, Gregor; Evans, Ronald M.; Lazar, Mitchell A.; Leid, Mark; De Lera, Angel R.; Lotan, Reuben; Mangelsdorf, David J.; Gronemeyer, Hinrich.
Pharmacological Reviews (2006), 58(4), 712-725.
Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARb /d agonists.
Pereira, Raquel; Furst, Audrey; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(24), 4514-4525.
The role of the 11-cis-retinal ring methyl substituents in visual pigment formation.
Dominguez, Marta; Alvarez, Rosana; Perez, Martin; Palczewski, Krzysztof; de Lera, Angel R..
ChemBioChem (2006), 7(11), 1815-1825.
A methyl group at C7 of 11-cis-retinal allows chromophore formation but affects rhodopsin activation.
Bosch, Laia; Cordomi, Arnau; Dominguez, Marta; Toledo, Darwin; Morillo, Margarita; Perez, Juan J.; Alvarez, Rosana; de Lera, Angel R.; Garriga, Pere.
Vision Research (2006), 46(27), 4472-4481.
Activity of alcohol dehydrogenase with 11-cis-retinoids and distribution of ADH4 in ocular tissues.
Porte, Sergio; Martras, Silvia; Martinez, Susana E.; Alvarez, Rosana; Gallego, Oriol; Dominguez, Marta; Duester, Gregg; de Lera, Angel R.; Farres, Jaume; Pares, Xavier.
Enzymology and Molecular Biology of Carbonyl Metabolism--12, [International Meeting], 12th, Burlington, VT, United States, July 6-11, 2004 (2006), Meeting Date 2004, 200-207.
The Stille Reaction in the Synthesis of the C37-Norcarotenoid Butenolide Pyrrhoxanthin. Scope and Limitations.
Vaz, Belen; Dominguez, Marta; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(16), 5914-5920.
Cycloisomerization of Activated (2E,4Z)-Heptatrienoate and Its Relevance to Crispatene (Bio)synthesis. A Case of Concerted and Stepwise Uncertainty.
Lopez, Carlos Silva; Faza, Olalla Nieto; Alvarez, Rosana; de Lera, Angel R..
Journal of Organic Chemistry (2006), 71(12), 4497-4501.
Computational Study and Analysis of the Kinetic Isotope Effects of the Rearrangement of cis-Bicyclo[4.2.0]oct-7-ene to cis,cis-Cycloocta-1,3-diene.
Silva Lopez, Carlos; Nieto Faza, Olalla; De Lera, Angel R..
Organic Letters (2006), 8(10), 2055-2058.
Natural and synthetic retinoids: structural bases and biological effects of potential clinical relevance for the prevention and treatment of infection-driven tumors.
Dolcetti, Riccardo; Di Luca, Dario; de Lera, Angel R..
Anti-Infective Agents in Medicinal Chemistry (2006), 5(1), 85-103.
Mechanism of the Gold(I)-Catalyzed Rautenstrauch Rearrangement: A Center-to-Helix-to-Center Chirality Transfer.
Nieto Faza, Olalla; Silva Lopez, Carlos; Alvarez, Rosana; De Lera, Angel R..
Journal of the American Chemical Society (2006), 128(7), 2434-2437.
Computation of vertical excitation energies of retinal and analogs: Scope and limitations.
Lopez, Carlos Silva; Faza, Olalla Nieto; Estevez, Susana Lopez; De Lera, Angel R..
Journal of Computational Chemistry (2006), 27(1), 116-123.
Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis.
Dominguez, Marta; Alvarez, Rosana; Borras, Emma; Farres, Jaume; Pares, Xavier; De Lera, Angel R..
Organic & Biomolecular Chemistry (2006), 4(1), 155-164.
Computational Characterization of a Complete Palladium-Catalyzed Cross-Coupling Process: The Associative Transmetalation in the Stille Reaction.
Alvarez, Rosana; Nieto Faza, Olalla; Silva Lopez, Carlos; de Lera, Angel R..
Organic Letters (2006), 8(1), 35-38.
Synthesis of the PPARb /d -selective agonist GW501516 and C4-thiazole-substituted analogs.
Pereira, Raquel; Gaudon, Claudine; Iglesias, Beatriz; Germain, Pierre; Gronemeyer, Hinrich; de Lera, Angel R..
Bioorganic & Medicinal Chemistry Letters (2006), 16(1), 49-54.
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2005
- Raquel Pereira, Claudine Gaudon, Beatriz Iglesias, Pierre Germain, Hinrich Gronemeyer and Angel R. de Lera
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs
Bioorg. Med. Chem. Lett. 2005, 16, 49-54 - Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Mechanistic subtleties in the cyclopentannelation of allenolate allyl carbamates: the origin of the center-to-center chirality transfer
Chem. Commun. 2005, 4285-4287 - Susana López, Virginia Rodríguez, Javier Montenegro, Carlos Saá Rosana Álvarez, Carlos Silva, Angel R. de Lera, Rosana Simón, Tzvetana Lazarova and Esteve Padrós
Synthesis of N-heteroaryl Retinoids and Their Artificial Bacteriorhodopsins
ChemBioChem 2005, 6, 2078-2087 - Fredy Sussman and Angel R. de Lera
Ligand Recognition by RAR and RXR Receptors: Binding and Selectivity
J. Med. Chem. 2005, 48, 6212-6219 - José A. Souto, Carlos Silva, Olalla Nieto Rosana Alvarez and Angel R. de Lera
2-Alkylidenesulfol-3-enes by (Regio and) Stereoselective Cheletropic Addition of SO2 to (Di)vinylallenes
Org. Lett. 2005, 7, 1565-1568 - Carlos Silva, Rosana Alvarez, Belén Vaz, Olalla Nieto and Angel R. de Lera
On the Simple Diastereoselectivity of the Vinylogous Mukaiyama Aldol Reaction of 2-Trimethylsiloxyfuran and Aldehydes
J. Org. Chem. 2005, 70, 3654-3659 - Angel R. de Lera
Design and Synthesis of RXR Modulators
Actualités de Chimie Thérapeutique, 2005, 31, 21-45 - Elena Korchemskaya, Nicolai Burykin, Angel R. de Lera, Rosana Alvarez, Sergey Pirutin and Anna B. Druzhko
14-Fluoro-bacteriorhodopsin gelatin films for dynamic holography recording
Photochem. Photobiol. 2005, xx, in press - Angela Nebossio, Nicole Clarke, Paola Bontempo, Emilie Volz, Rosana Alvarez, Ettore M. Schiavone, Alexssandro Weisz, Francesco Bresciani, Angel R. de Lera, Hinrich Gronemeyer and Lucia Altucci
Tumor-selective action of HDAC Inhibitors involves TRAIL induction in acute myeloid leukemia cells
Nature Medicine 2005, 11, 77-84 - Anna B. Druzhko, Sergey K. Pirutin, Angel R. de Lera, Rosana Alvarez and Howard, H. Weetall
Effect of Dehydration on Photoinduced Transformation in Gelatin Films Made of WT and D96N 14-Fluoro-bacteriorhodopsin
Appl. Biochem. Biotechnol. 2005, 120, 121-132 - Belén Vaz, Rosana Alvarez, Reinhard Brückner and Angel R. de Lera
The Stille Reaction in the Synthesis of Carotenoid Butenolides: Synthesis of 6'-epi-Peridinin
Org. Lett. 2005, 7, 545-548 - Belén Vaz, José A. Souto, Rosana Alvarez and Angel R. de Lera
γ-Allenylated Allyl Benzothiazole Sulfonyl Anions Undergo cis-Selective (Sylvestre) Julia Olefinations
Synlett. 2005, 294-298 - Vivian Pogenberg, Jean-François Guichou, Valie Vivat-Hannah, Sabrina Kammerer, Efrén Pérez, Pierre Germain, Angel R. de Lera, Hinrich Gronemeyer, Catherine A. Royer and William Bourguet
Characterization of the Interaction Between RAR/RXR Heterodimers and Transcriptional Coactivators Through Structural and Fluorescence Anisotropy Studies
J. Biol. Chem. 2005, 280, 1625-1633 - Carlos Silva, Olalla Nieto, Fernando P. Coss�, Darrin M. York and Angel R. de Lera
Ellipticity: A Convenient Tool to Characterize Electrocyclic Reactions
Chemistry: Eur. J. 2005, 11, 1734-1738 - Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
Pseudorotation Barriers of Biological Oxyphosphoranes: A Challenge for Simulations of Ribozyme Catalysis
Chemistry: Eur. J. 2005, 11, 2081-2093
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2004
- Silvia Martras, Rosana Alvarez, Susana E. Martínez, Dámaso Torres, Oriol Gallego, Gregg Duester, Jaume Farrés, Angel R. de Lera and Xavier
Par�
The Specicifity of Alcohol Dehydrogenase With cis-Retinoids. Activity with 11-cis-Retinol and Localization in Retina
Eur. J. Biochem. 2004, 271, 1660-1670 - A. B. Druzhko, S. K. Pirutin, A. R. de Lera, R. Alvarez, S. Alvarez and M. Dom�guez
14-Fluorobacteriorhodopsin gelatin films: performance at different relative humidities
J. Biol. Phys. Chem. 2004, 4, 11-16. - Susana Alvarez, Rosana Alvarez and Angel R. de Lera
Enantioselective Synthesis of all of the Stereoisomers of (E)-13,14-Dihydroxyretinol (DHR)
Tetrahedron:Asymmetry 2004, 15, 839-846 - Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Conrotatory Ring Opening Reactions of Cyclopropyl Anions in Monocyclic and Tricyclic Systems
Org. Lett. 2004, 6, 901-904 - Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
The Woodward-Hoffmann-DePuy rule revisited
Org. Lett. 2004, 6, 905-908 - Carlos Silva, Olalla Nieto, Brent A. Gregersen, X. L�ez, Angel R. de Lera and D. M. York
Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis
Chem. Phys. Chem. 2004, 5, 1045-1049 - Carlos Silva, Olalla Nieto, Darrin M. York and Angel R. de Lera
Theoretical Study of the Vinyl Allene Oxide to Cyclopent-2-en-1-one Rearrangement: Mechanism, Torquoselectivity and Solvent Effects
J. Org. Chem. 2004, 69, 3635-3644 - Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Theoretical Study of the Electrocyclic Ring Closure of Hydroxypentadienyl Cations
Chem. Eur. J. 2004, 10, 4324-4333 - Pierre Gemain, Sabrina Kammerer, Efrén Pérez, Carole Peluso-Iltis, David Tortolani, F. Cristopher Zusi, John Starrett, Philippe Lapointe, Jean-Paull Daris,
Anne Marinier, Angel R. de Lera, Natasha Rochel, Hinrich Gronemeyer
Rational design of RAR selective agonists revealed by RAR-β crystal structure
EMBO Rep. 2004, 5, 877-882 - Silvia Martras, Rosana Alvarez, Oriol Gallego, Marta Domínguez, Angel R. de Lera, Jaume Farrés and Xavier Pares
Kinetics of alcohol dehydrogenase with cyclohexenyl ring oxidized retinoids. Effect of Tween 80 on the kinetics and the stability of retinoids
Arch. Biochem. Biophys. 2004, 430, 210-217 - Rosana Alvarez, M. Jess Vega, Sabrina Kammerer, Aurèlie Rossin, Pierre Germain, Hinrich Gronemeyer and Angel R. de Lera
9-cis Retinoic Acid Analogues With Bulky Hydrophobic Rings: New RXR-Selective Agonists
Bioorg. Med. Chem. Lett. 2004, 14, 6117-6122 - Marta Domínguez, Rosana Alvarez, Silvia Martras, Jaume Farré, Xavier Parés and Angel R. de Lera
Synthesis of Ring-oxidized Retinoids as Substrates of Mouse Class I Alcohol Dehydrogenase (ADH1)
Org. Biomol. Chem. 2004, 2, 3368-3373 - Olalla Nieto, Carlos Silva, Rosana Alvarez and Angel R. de Lera
Solvolytic Ring Opening Reactions of Cyclopropyl Halides. An Assessment of the Woodward-Hoffmann-DePuy Rule
J. Org. Chem. 2004, 69, 9002-9010
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2003
- Beatriz Domínguez, Rosana Alvarez and Angel R. de Lera
Recent Advances in the Synthesis of Retinoids
Org. Prep. Proc. Int. 2003, 35, 239-306 - Rosana Alvarez, Marta Domínguez, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
9Z- and 11Z-8-Methylretinals for Artificial Visual Pigment Studies. Stereoselective Synthesis, Structure and Binding Modeling
Chem. Eur. J., 2003, 9, 5821-5831
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2002
- Istvan Szundi, Angel R. de Lera, Yolanda Pazos, Rosana Alvarez, Marco Oliana, Mordechai Sheves, James W. Lewis and David S. Kliger
Bleaching kinetics of artificial visual pigments with modifications near the ring/polyene chain connection
Biochemistry 2002, 41, 2028-2035 - Angel R. de Lera and Fernando P. Cossío
Reply to Electrocyclization of (Z)-1,2,4,6-Heptatetraene and Its Heterosubstituted Analogs: Pericyclic or Pseudopericyclic?
Angew. Chem. Int. Ed. 2002,41, 1150-1152 - Belén Vaz, Rosana Alvarez and Angel R. de Lera
Synthesis of Symmetrical Carotenoids by a Two-fold Stille Coupling
J. Org. Chem. 2002, 67, 5040-5043 - M. Paz Otero, Alicia Torrado, Yolanda Pazos, Fredy Sussman and Angel R. de Lera
Stereoselective Synthesis of Annular 9-cis-Retinoids and Binding Characterization to the Retinoid X Receptor
J. Org. Chem. 2002, 67, 5876-5882 - Beatriz Domínguez, M. Jess Vega, Fredy Sussman and Angel R. de Lera
Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
Bioorg. Med. Chem. Lett. 2002, 12, 2607-2609
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2001
- Anna B. Druzhko, V.Y. Shakhbazian, Rosana Alvarez, Angel R. de Lera and Howard H. Weetall
Photoinduced Transformation of 14-F-Bacteriorhodopsin Gelatin Films Based on Both Wild Type and D96N Mutants
Biosystems 2001, 59, 53-60 - Rosana Alvarez, Beatriz Domínguez and Angel R. de Lera
An Expedient Stereocontrolled Synthesis of 7-cis-Retinoids
Synth. Commun. 2001, 31, 2083-2087 - Angel R. de Lera, Rosana Alvarez, Begoña Lecea, Alicia Torrado and Fernando P. Cossío
On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4,5-trienals and their Schiff Bases
Angew. Chem. Int. Ed. 2001, 40, 557-561 - Beatriz Iglesias, Rosana Alvarez and Angel R. de Lera
A General Synthesis of Alkylpyridines
Tetrahedron 2001, 57, 3125-3130 - Raquel Pereira, Beatriz Iglesias and Angel R. de Lera
A Reactivity Optimization Study for 2,3-Dibromothiophene and Its Application in the Synthesis of Novel Disubstituted Thiophene Derivatives
Tetrahedron 2001, 57, 7871-7881 - Belén Vaz, Rosana Alvarez, Mar Nieto, Antonio I. Paniello and Angel R. de Lera
Suzuki cross-coupling of meso-dibromoporphyrins for the synthesis of functionalized A2B2 porphyrins
Tetrahedron Lett. 2001, 42, 7409-7412 - Yolanda Pazos, Beatriz Iglesias and Angel R. de Lera
The Suzuki reaction in the stereocontrolled synthesis of 9-cis-retinoic acid and analogs
J. Org. Chem. 2001, 66, 8483-8489
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2000
- Beatriz Iglesias, Alicia Torrado, Susana L�ez and Angel R. de Lera
A Pericyclic Cascade to the Stereocontrolled Synthesis of 9-cis-Retinoids
J. Org. Chem. 2000, 65, 2696-2705 - Howard H. Weetall , Anna B. Druzhko, Angel R. de Lera, Rosana Alvarez and Baldwin Robertson
Measurement of Proton Release and Uptake by Analogs of Bacteriorhodopsin
Bioelectrochemistry, 2000, 51, 27-33 - Angel R. de Lera, Beatriz Iglesias, Susana López and Jesús Rodríguez
Torqueselectivity on the Cationic Cyclopentannelation of (2Z)-Divinylallenal Acetals
Chem. Eur. J., 2000, 6, 4021-4033 - Beatriz Domínguez, Yolanda Pazos and Angel R. de Lera
Stereocontrolled Synthesis of 6-s-cis and 6-s-trans-Locked 9Z-Retinoids by Hydroxyl-Accelerated Stille Coupling of (Z)-Tri-n-Butylstannyl but-2-en-1-ol and Bicyclic Dienyl Triflates
J. Org. Chem. 2000, 65, 5917-5925 - J. K. McBee, V. Kuksa, R. Alvarez, Angel R. de Lera, O. Prezhdo, F. Haeseleer, I. Sokal and K. Palczewski
Isomerization of all-trans-Retinol to cis-Retinols in Bovine Retinal Pigment Epithelial Cells: Dependence on the Specificity of Retinoid-Binding Proteins
Biochemistry 2000, 39, 11370-11380
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